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A key mechanism involves the translocation of the antioxidant transcription factor Nrf2 from the cytoplasm to the nucleus, where it binds the antioxidant response element (ARE) and enhances the expression of antioxidant genes, such as superoxide dismutase ( SOD ), glutathione peroxidase ( GPx ), and heme oxygenase-1 ( HO-1 )

Xuping Zhang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

These findings (Figure 9) are consistent with the H 2 O 2 sensitivity of sll1545 cells (Figure 8)

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10.17179/excli2021-4211 185 PetersR.BurdockG