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Several risk genes encode voltage-gated calcium and chloride channels known to modulate glutamate receptor activity (CACNA1C and CLCN3), metabotropic receptors (glutamate (GRM1) and GABA (GABBR2)), and the NMDA-R subunit (GRIN2A)

Because up to 50% of infertility cases involve issues with sperm

In cases where encapsulation efficiency is low, patients may not receive the intended dose of the drug, leading to suboptimal treatment efficacy [343]

If, however, you're designing a study specifically to test the local gut effects of peptides, then an oral formulation might be your test article, but you'd be doing so with the full understanding of its limitations

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