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[7,8] Several risk factors have been proposed for this disease

Diabe- tes 23:117-125 Varandani PT, Nafz MA (1976) Insulin degradation

[212] There is growing appreciation of the importance of the pleiotropic hormone vitamin D in the development of tolerance, immune system defenses, and epithelial barrier integrity [213] 1,25(OH)2D3 (vitamin D) may play a protective role in mucosal barrier homeostasis by maintaining the integrity of junction complexes and in healing capacity of the colon epithelium