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doi: 10.1158/2159-8290.CD-18-0798

Bone loss in primary biliary cirrhosis: absence of association with severity of liver disease

In other words, toxicity from B12 is extremely rare

Given the well-establish immunological involvement of gut microbiota in humans, efforts have been made to determine the functions of individual microbes in context of the pathways involved in metabolism of nutrients (Yadav et al., 2018)