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A meta-analysis of OLP patient data revealed that smokers had a significantly greater rate of malignant transformation than nonsmokers (Aghbari et al., 2017)

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While innovation in medicine is important, it should proceed via clinical trials, not by leapfrogging around regulations and experimenting on those who trust us

This process is morphologically marked by small mitochondria with condensed membrane densities, and biochemically by iron overload and GSH depletion, leading to loss of antioxidant defense and irreversible oxidative damage ( 3.2 Key molecular drivers of ferroptosis Iron Overload: Excess intracellular ferrous iron (Fe 2+ ) catalyzes the Fenton reaction, producing hydroxyl radicals (OH) that initiate lipid peroxidation cascades

The 96-well plate was gently shaken for a few seconds and absorbance was read at 340 nm once every minute for 10 min, or to obtain readings at a minimum of 5 time points