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6.3 Mechanistic understanding and complex interactions Although substantial progress has been found in recognizing the core pathways by which exercise may exert therapeutic effectsnamely through the regulation of oxidative stress and HPA axis functionour insight of the complicated relationship between these mechanisms continues to be incomplete

While mitochondrial morphology was unaltered after 3 weeks of hyperglycemia, electron microscopy revealed distorted vacuous mitochondria with decreased matrix electron density after 5 weeks of hyperglycemia, accompanied by increased proteolytic cleavage of Opa1 leading to more fragmented mitochondria due to impaired fusion [109]

Mendes R, Pedrosa P, Lima JC, Fernandes AR, Baptista PV (2017) Photothermal enhancement of chemotherapy in breast cancer by visible irradiation of Gold Nanoparticles

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