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GLS-1 and GLS-2 may serve as diagnostic and therapeutic targets for certain cancers

Both PAT and OPZ were here efficient, noncompetitive inhibitors of TGR (Figure 3)

IL-6 and IL-1 stimulate expression of hepcidin, the iron-regulatory hormone, causing degradation of ferroportin and iron retention in macrophages, which elevates labile Fe and lipid peroxidation [47, 48]