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It stimulates the immune system, aids circulation, increases tissue oxygenation, and has antiaging effects

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Mitogen-activated protein kinase p38 (p38 MAPK) also participates in the induction of the SASP, but this occurs independently of the DDR pathway (Freund et al., 2011)

Furthermore, as trauma is undoubtedly at the origin of PD and even micro-injuries may bear serious consequences in genetically predisposed patients, even injections must be considered a source of microtrauma for the tissues, therefore we made sure to use a very thin needle when performing the injections in the area around the plaque, and we decreased the number of injections at every treatment cycle