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Future innovations might even include real-time feedback systems, like wearables or smart patches, that track microbiome shifts and provide instant insights into how lifestyle factors affect skin health

While the direct relationship between autosis and BPD remains unclear, the autophagy-mitochondrial axis warrants attention: (1) Autophagy dysregulation (e.g., via Rubicon-Beclin1-Na + /K + -ATPase pathway disruption): may promote cell death by impairing mitochondrial quality control (Li Y

Boveris, A., Oshino, N

Dysregulation of MCT4 has been observed, with increased MCT4 expression detected in hypoxia-induced PH models and hypoxia-treated PAECs [75]

Bocian-Jastrzebska, A., Malczewska-Herman, A