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This mitochondrial support manifests through several mechanisms: Comprehensive mitochondrial protection : Hydrogen's ability to penetrate mitochondria complements manganese SOD (requiring manganese), glutathione peroxidase (requiring selenium), and CoQ10 (requiring B vitamins for synthesis), creating multi-layered mitochondrial defense

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Additionally, berberine demonstrated strong binding affinity to the allosteric sites of AMP-activated protein kinase (AMPK) - and -subunits, which could contribute to the modulation of inflammatory responses as well (107)

Wang J, Xu M, Liang R, Zhao M, Zhang Z, Li Y (2015b) Oral administration of marine collagen peptides prepared from chum salmon ( Oncorhynchus keta ) improves wound healing following cesarean section in rats

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