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Dopamine neurons projecting to medial shell of the nucleus accumbens drive heroin reinforcement

doi:10.1146/annurev.pharmtox.45.120403.095857 [PubMed] 15

Research on combination approaches remains limited, but the distinct delivery pathways suggest potential synergy

Its primary function involves degrading reduced GSH, thereby disrupting GSH redox balance and shifting the cell towards a more oxidized state

For instance, copper-based nanoparticles (which is discussed in a separate section) such as CuTCPP@MOF nanodots@Mannosamine induce cuproptosis and ferroptosis in macrophages via oxidative stress, thus eliminating intracellular pathogens and enhancing antimicrobial responses [236]