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These are one of, if not the most rigorously studied class of peptides ever, with many large, placebo-controlled, randomized trials that followed over the past twenty years from the original GLP-1 drugs such as exenatide, approved by the FDA in 2005

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They have been implicated in various processes, including endocytosis, signalling, lipid regulation and mechanosensing

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Once the stores have been replaced then only maintenance injections will be required, depending on the reasons for the deficiency