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Increased efflux of anticancerous drugs is a mechanism by which drug resistance is achieved leading to lower drug levels within the cells [181]

3.4 Poor outcomes and immunosuppressive drugs administered during follow-up in patients with AAV During follow-up after diagnosis, among the 71 patients, 6 (8.5%) died, and 17, four, and one had ever experienced and suffered from ESKD, CVA, and ACS, respectively