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Additionally, CD8 + T cells play an important role in OA cartilage damage

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All of these processes are closely associated with tumor development.HDAC inhibitors inhibits tumor development through various pathways, such as hyperacetylating histones, and activates a variety of transcription factors.HDAC inhibitors can thus inhibit cancer via altering target gene expression, blocking the cell cycle, and promoting tumor cell senescence [46]

however, they were not greater than levels from male Gclc L-KO mice (Fig