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These studies show increased NAD+ metabolites and report potential improvements in fatigue, sleep, and mood

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Yee AZH, et al

Compared to mice with a global alcohol dehydrogenase 2 gene knockout ( Aldh2) , which exhibit remarkably higher blood acetaldehyde concentrations following acute oral alcohol administration than wild-type controls, mice with hepatocyte-specific Aldh2 deletion showed only about a 50% increase in systemic acetaldehyde (123)