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An intratumoral injectable nanozyme hydrogel for hypoxia-resistant thermoradiotherapy

It adversely affects brain homeostasis through BBB dysfunction and hyperthermia ( Various METH dosing paradigms significantly disturb endothelial TJ assembly by inducing downregulation, fragmentation, or redistribution of major TJ proteins, including claudin-5 and ZO-1, which are mediated by MMP-1 and MMP-9 peptidases

The retinoblastoma gene (Rb) encodes a tumour suppressor protein critical for controlling the G1 checkpoint of the cell cycle, which regulates the transition from G1 to S phase

A submerged platform (10 cm2), painted white was placed in target quadrant 1 cm below surface of water so as to provide escape area

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