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Targeted deletion of IL33 in stromal cells using compartment-specific knockout mouse models results in increased CD8 + T-cell infiltration and activation, reprogramming of the tumor microenvironment-including CAFs and myeloid cells-toward a less immunosuppressive state, and a reduction in tumor growth [138]

Liver cirrhosis, a frequent complication resulting from MASH, is not only the leading cause of HCC but also the second most common indication for liver transplantation in the USA [11]

Disorders of glutathione synthesis and metabolism (z B Deficiency of amino acids, glutathione reductase or glutathione peroxidase)

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10.1038/s41467-020-15711-0 161 WangC.ChenL.ZhuJ.WangC.LiM.MiaoY.et al (2024)