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Vitamin E is a fat-soluble vitamin with antioxidant properties

Figure 2 Both insoluble fibrils and soluble A oligomers exert potent neurotoxicity by forming plaques and triggering pathological cascades, including synaptic failure, excitotoxicity, changes in membrane permeability, and chronic inflammation (77, 78)

This in vitro fertilization (IVF)-based technique involves culturing a fertilized egg containing the pathogenic mtDNA mutation until it reaches the 68 cell or blastocyst stage

Furthermore, methylation of hMSH2 in Lynch syndrome kindreds has been shown to be transmitted genetically [35] and to follow Mendelian inheritance, in contrast to epimutation of hMLH1

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