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Diabetes Over the last two decades, diabetes has emerged as a significant global health issue, affecting approximately 463 million adults worldwide [144]

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Subacromial bursitis: The subacromial bursa is a fluid-filled sac that reduces friction in the shoulder

N-methyl-d-aspartate receptor (NMDA-R) plays a crucial role in ischemic neuronal injury, cerebral vascular endothelial exposure to exogenous oxidative stress upregulates the expression of functional NMDA-R, and NF-B activation is involved in the up-regulation of functional NMDA-R, treatment of bEnd3 cells with an inhibitor of NF-B activation completely blocks ROS-induced up-regulation of NR1 subunit and depolarization of NMDA receptor after ROS exposure, Upregulation of NMDA-R expression increases endothelial response to glutamate stimulation and promotes BBB rupture (Neuhaus et al., 2011