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The intravenous administration of amifostine can cause significant adverse effects, including nausea, hypotension, and vomiting

Moreover, an in-depth analysis of these DEGs revealed significant enrichment in pathways including the cAMP signaling pathway, Rap1 signaling pathway, cGMP-PKG signaling pathway, Phospholipase D signaling pathway, insulin signaling pathway, insulin resistance, Glucagon signaling pathway and PPAR signaling pathway, which were closely implicated in lipid metabolism, as supported by previous studies (Fig

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This highlights the significance of moderate mitophagy in maintaining neural cell health [94]

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