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The latter has been involved in increased activity of pro-inflammatory cytokines that promote disease progression to steatohepatitis and cirrhosis (Bellanti et al., 2017)

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As such, administration of bacterial mimetic lipopolysaccharide (LPS) to pregnant mice on embryonic day 14 increases maternal circulating levels of interleukin (IL)-17, a T cell-derived proinflammatory cytokine, and subsequently leads to increased ASD-like impaired vocalization and social approach behaviors in their offspring [52]

10.1208/s12249-019-1353-8 197 SantonocitoD.RacitiG.CampisiA.SpositoG.PanicoA.SicilianoE

Gene function annotation was performed using the following databases: non-redundant protein database (NR), PFAM, Clusters of Orthologous Groups for eukaryotic whole genomes (KOG), COG, Swiss-Prot protein, KEGG, KO, and Gene Ontology (GO) (Tang et al., 2022