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This pathways functions in cancer cells have been substantially overlooked, with only a few relevant studies having been reported

Summary Keywords amodiaquine, quinoneimine, cytotoxicity, endoplasmic reticulum stress, human glutathione S -transferases P1 Citation Zhang Y, den Braver-Sewradj SP, den Braver MW, Hiemstra S, Vermeulen NPE, van de Water B, Commandeur JNM and Vos JC (2018) Glutathione S -Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells

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Conclusion: PHEGAESUS presents a novel PGAS-based approach to obtain mechanistic insights and to enable personalised approaches in diagnosis and treatment of ischaemic stroke by integrating genetic and phenotypic data and circulating biomarkers