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[80] FosB plays a crucial role in the development of drug addictions, since its overexpression in D1-type medium spiny neurons in the nucleus accumbens is necessary and sufficient [note 6] for most of the behavioral and neural adaptations that arise from addiction

Physiol Rev 93:121

Moreover, the application of systems biology frameworks allows for the integration of diverse datasets, enabling the identification of potential biomarkers and therapeutic targets that can be further validated in clinical settings

Because cannabinoid receptor 1 (CB1) activation results in inhibition of selective adenylate cyclase activity, THC binding to CB1 receptors may affect perception, memory, and movement, and may trigger depression