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Immune mechanisms linking sleep deprivation and diseases As shown above, sleep deprivation has been found to alter inflammatory immune processes via multiple pathways, which could lead to increased susceptibility to chronic inflammatory diseases (Fig

209 TGF- is secreted in response to inflammation, hypoxia, ROS, etc., and triggers the SMAD2/3/SMAD4/p21/p15 pathway to induce irreversible cell cycle arrest

These activated T cells then release pathogenic inflammatory cytokines, contributing to the development of autoimmune diseases (96)

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