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Adjuvant Methotrexate in the Radiotherapeutic Management of Advanced Tumors of the Head and Neck

Among them, IL-1 and TNF- can enhance the expression of COX-2, PGE2 and MMPs in human RASFs (158, 188, 190), and play an important role in the development of RA

Deficiency in these elements can lead to spermatogenesis disorders and fertility problems and abnormal progesterone concentrations and acrosome reactions in human sperm, respectively (111)