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Description

Derivatization strategies for the detection of triamcinolone acetonide in cartilage by using matrix-assisted laser desorption/ionization mass spectrometry imaging

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Fibrosis is defined as the overabundant deposition of the extracellular matrix (ECM), which includes collagen and fibronectin (FN), leading to the accumulation of substantial fibrous connective tissue in areas of inflammatory infiltration or within and around damaged tissues (1)

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Funding This research was supported by the China Postdoctoral Science Foundation (2021M701420), Guangdong Basic and Applied Basic Research Foundation (2022A1515110021), Guangzhou Science and Technology Projects Foundation (202201020002), Scientific Research Project of Guangdong TCM Bureau (20221105), Guangdong Medical Research Foundation (A2022214)

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Results We previously mined the PDB for proteins with CSDs, the most common type of forbidden disulfide (Haworth and Wouters, 2014)

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Crescent J Med Biol Sci

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