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Intriguingly, while VRK2 wild-type tumors were resistant to APR-017 monotherapy, combinatorial treatment with the VRK2 inhibitor IC261 restored their sensitivity to APR-017 (Fig

Adult stem cells, including NSCs, HSCs, MSCs, and ESCs, serve as progenitor cells for their respective tissues and organs, possessing the ability to differentiate into specialized functional cells [281]