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This is largely due to the prevalence of genetic variations in the MTHFR (methylenetetrahydrofolate reductase) gene

10.1371/journal.pone.0133896 PLoS One 266 YinR.MaoS

The most significant risk factors for advanced fibrosis in both sexes were obesity (BMI), abdominal obesity (waist circumference and waist-hip ratio), insulin resistance (HOMA-IR), and elevated transaminases (p 40 IU (p 30g/day), and mixed MAFLD (MAFLD and alcohol-related cirrhosis)