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Rapid weight reduction can signal energy deficit to the hypothalamus, potentially suppressing gonadotropin-releasing hormone (GnRH) pulsatility

Tirzepatide 50% to 57% of participants in the 10 mg and 15 mg groups achieved 20% or more body weight reduction at week 72

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Mnguez-Alarcn L, Gaskins AJ, Chiu YH, et al