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Results: DDC mice had increased AST, ALT, bilirubin, bile acids, ductular reaction and macrophage infiltration and reduced hepatocyte mRNA expression of Abcb11, Abcg8, Nr0b2 (SHP), Nr5a2 and Abcc2 mRNA relative to chow fed mice

Clean the injection site with an alcohol swab, pinch a fold of skin, insert the needle at a 45-degree angle, inject slowly, and hold for a few seconds before withdrawing

Examples include Vitex agnus-castus (chasteberry), black cohosh, or dong quai

Oxidative stress, energy metabolism disorders, and inflammatory responses that occur during this process cause severe damage to myocardial cells

3.3.1 Estrogen maintains mitochondrial health via the PGC-1 signaling axis, inhibiting ferroptosis One of the core mechanisms of estrogens protective effect on mitochondria is through the activation of peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1), a master regulator of mitochondrial biogenesis