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A comprehensive review of arginase inhibitors can be found in Pudlo et al

From the available studies, it is evident that BM increases CREB phosphorylation and reduces TNF- , IL-1, IL-6, NF-B and MIP-1b, in different brain regions, which results in reduced neuroinflammation that also controls disease progression

Fibrinogen may be an important target for methylglyoxal-derived AGE modification in elastic arteries of humans

Examples include sequential release systems (e.g., GSH depletion followed by ROS generation), self-sustaining cycles (e.g., catalytic O 2 production to enhance sonodynamic or photodynamic therapy), or conditionally activated systems (e.g., hypoxia-triggered prodrug activation) (155, 166)

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