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Finally, the fourth mechanism entails target modification, which can occur through mutations, enzymatic alterations, and replacement 19,64,65

the central nervous system neurodegenerative disorder associated with oxidative stress is selected from the group consisting of Parkinson's disease, Alzheimer's disease, basal ganglia degenerative diseases, motoneuron diseases, Scrapie, spongyform encephalopathy and Creutzfeldt-Jakob's disease

Systemic loss of metabolic coordination in tumor-bearing mice A disturbance in metabolic homeostasis is a defining characteristic of cancer

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Pathogenesis of the hyperthyroidism of Gravess disease