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The control for possible confounding (e.g., age, obesity, smoking) generally was not performed (only in one study)

Emerging platforms, such as gold nanoparticles or bioreducible lipid nanoparticles, further enhance this synergy by facilitating endosomal escape and intracellular release of Cas9-sgRNA ribonucleoproteins (RNPs) [310]

376,377 Although some evidence points to a Gq/11-like extralarge G protein (GXL)-IP3-PKC pathway in FGF23 induction, 378 its role in LPA signaling remains unclear

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Current treatment modalities and limitations Pharmacological treatment remains the primary current approach to managing PD, with levodopa considered the gold standard for alleviating motor symptoms 51