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Cell 16 20912105 10.1091/mbc.E04-08-0737 [DOI] [PMC free article] [PubMed] [Google Scholar] Pompella A., Visvikis A., Paolicchi A., De Tata V., Casini A

Anso E, Mullen AR, Felsher DW, Mates JM, Deberardinis RJ, Chandel NS

This mechanism occurs in addition to spontaneous S -glutathionylation favored by oxidative conditions

It is a naturally occurring molecule your body already produces it

TAFs interact with stromal cells by secreting growth factors, cytokines, and chemokines, including IL6, TGF, and CCL2, to amplify immune evasion systems, attracting immunosuppressive cells into the tumor microenvironment, and they also form a network of proinflammatory mediators at the tumor site