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In DCM, upregulation of the copper importer SLC31A1 makes patients exceptionally sensitive to chelators, whereby a standard dose can precipitate severe deficiency [240]

Yes, excessive alcohol intake may worsen nutritional deficiencies and reduce the effectiveness of vitamin supplementation

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It also increases production of decorin, dermatan sulfate, and chondroitin sulfate key components of the extracellular matrix that provide tissue structure and hydration (PMID: 12270842)

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