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Correspondingly, in vivo treatment of tumors with JHU-083 had an increased the number of CD8 + tumor-infiltrating lymphocytes (TILs), and their transcriptional program showed an enhanced proliferative capacity and anti-cancer activity, and the expression of genes related to long-term memory CD8 + T cells was up-regulated, while the expression of genes related to apoptosis was significantly down-regulated

For ROS analysis, cells were stained with 10 M H 2 DCFDA (Invitrogen, D399) for 30 min at 37 C

Without GSH, these peroxides would rapidly destroy the lipid membranes that encase our cells and our mitochondria, leading to catastrophic cellular failure

Y.KaurA.LamotheL.ShaikhM.KeshavarzianA.et al