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It is reported that PGC-1 affects cellular oxidative capacity and fatty acid oxidation through the regulation of mitochondrial and nuclear genes 13,14

To view a copy of this license, visit About this article Cite this article Ibrahim, I.M., Wu, H., Ezhov, R

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

Rapamycin, which induces autophagy through the inhibition of mTORC1, and wortmannin, which inhibits autophagy through inhibition of phosphatidylinositol-3-kinase (PI3K), were used as controls (Powis et al., 1994

2024), the ferroptotic cell death was confirmed by the reduced expression of GSH, GPX-4, ferritin heavy chain (FTH) and SQSTM1, while nuclear receptor coactivator4 (NCOA4) and LC3II/I were markedly upregulated