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Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene

However, in addition to these reversible modifications, several cysteine adducts can form irreversibly due to prolonged exposure of cysteine residues to ROS and RNS, such as sulfinic or sulfonic acids (Chouchani et al., 2011

In the present study, we focus on -OHB mainly because it is one of the most predominant ketone bodies in the ketogenic diet, accounting for 78% of the total number of plasma ketone bodies, and has a wide range of metabolic modulatory functions in both physiologic and pathologic states

Tai, L., Huang, C

Crystal structures of the PARKIN1receptor (PDB code: 1MG8) [23], CREB (PDB code: 1KDX) [24], PINK (PDB code: 6EQI) [25], and TrkB receptor (PDB code: 5MO9) [26] were acquired from the RCSB Protein Data Bank ( [27]