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To assess the robustness of the findings, additional sensitivity analyses were performed using spline-based ANCOVA with cubic regression splines to accommodate potential non-linear relationships between age and metabolite abundance

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Piperlongumine (PL), an oxidative stress inducer, inhibits ZIKV replication in various cells, including the human brain microvascular, Vero, and human umbilical vein endothelial cells 129

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Lacerata, A

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In addition, esculetin (25 mg/kg) decreases immobility time and climbing time in the forced swim task elicited in acute restraint stress-induced rats by restoring the activities of antioxidant enzymes including CAT, SOD, GPx and GSH, and reducing the levels of GSSG in rat cortical areas (44)

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