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27 However, when potential initiating events were investigated, the authors provided evidence that erastin inhibits system X c -, a Na + -independent cystine/glutamate antiporter responsible for cystine uptake into the cell, thereby promoting glutathione synthesis

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Furthermore, its heme production reached up to 1,034 mg/L by increasing cell density, regular iron supplementation, and supply of excess feeding solution (Choi et al