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Cyclosporine-induced renal injury is believed to be mediated via vasculopathy, which reduces blood supply to the kidney

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10.1016/j.neubiorev.2017.03.007 61 LeeJ.HyunD

For the proteomic analysis, 300 L aliquots of urine were centrifuged twice at 10,000 g for 20 min at 4C to separate urinary proteins from small molecules using an Amicon Ultra 0.5 ml Centrifugal Filter (10 kDa, UFC501096, Merck Millipore, Darmstadt, Germany) according to the manufacturers instructions

Over time, these small injuries can add to wear and tear in the hip joint