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Generally, the clinical presentation is rather indistinct, but is characterized by fever a few days to weeks after a tick bite, accompanied by non-specific influenza-like symptoms, including chills, fatigue, headache, myalgia and arthralgia (Platonov et al., 2011)

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PFK-2 regulates intracellular levels of the glycolytic intermediate fructose-2,6-bisphosphate (F-2,6-BP), as it has dual kinase:bisphosphatase activities and thus catalyzes both the synthesis and degradation of this intermediate