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Salinity Stress Salinity stress is considered one of the most severe constraints to agricultural production globally, affecting close to 20% of the irrigated land and forecasted to affect up to 50% of the land by the year 2050, becoming a major concern for global food security (Hussain et al., 2016

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Elevated systemic and urinary lactate levels, corroborated by upregulation of glycolytic enzymes in renal tissue, may delineate a high-lactate DKD phenotype characterized by more aggressive fibro-inflammatory activity and a potentially faster trajectory of renal function loss [91]