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Feb 2003;28(1):53-9

Animal studies even really promising ones dont automatically translate to human safety data, and compounding pharmacies were scaling up production of a substance that had never cleared that bar

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Song et al showed that decreasing periplasmic GSH by deleting the GSH exporter CydD triggers the CpxR/SoxS two-component systems, upregulating the AcrAB-TolC pump and lowering intracellular drug accumulation