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In addition, the metabolites obacunone and itaconate significantly reduced lung injury by inducing activation of the NRF2 pathway (108, 109)

Several observations, however, are undisputed: (i) corticosteroids are effective [91], (ii) superpotent topical corticosteroids applied in large quantities (initially 40 g/day) on the entire body are as effective as oral predniso(lo)ne at a starting dose of 0.5 mg/kg/day [91], (iii) predniso(lo)ne at a starting dose of 1.0 mg/kg/day is associated with a higher number of severe adverse events and increased mortality compared with predniso(lo)ne at a starting dose of 0.5 mg/kg/day [91], (iv) doxycycline 200 mg/day is effective, although significantly less than predniso(lo)ne at a starting dose of 0.5 mg/kg/day [92], (v) dapsone 1.5 mg/kg/day is effective and has a higher corticosteroid-sparing potential than azathioprine 1.52.5 mg/kg/day [93], and (vi) IVIG 2 g/kg body weight/day is effective [94]

Ageeva-Kieferle A, Rudolf EE, Lindermayr C

For all diabetic patients, especially those at risk of foot ulcerations, education on foot care, including disease awareness and self-care strategies, should be provided

23.0% LTC (77.0% LTFU) and 4.1% Tx initiated in SOC