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Current research priorities include large-scale studies to better understand the tissue-specific effects of NNMT inhibition and the temporal dynamics of metabolic reprogramming following treatment

Plasma lipid-profile measurements showed that the total cholesterol levels were ~30% lower in treated DIO mice relative to control DIO mice ( P 15% relative to NNMT) human methyltransferases (e.g., COMT) or functionally distinct SAM-dependent DNA (e.g., DNMT1) and protein (e.g., PRMT3) methyltransferases with primary and tertiary structures highly similar to NNMT

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