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Severe liver disease, especially alcoholic and cirrhotic, as these conditions are often associated with folate deficiency and reduced levels of the enzymes responsible for homocysteine metabolism

It was identified in the late 1980s and initially attracted attention because its deposits are found in the pancreases of people with type 2 diabetes

Ensure storage in tightly sealed containers or vials to protect them from moisture and air exposure, preserving their quality and extending shelf life for research or therapeutic use

Therefore, complementary strategies to protect OLs and induce the generation of new remyelinating OLs are urgently needed to promote repair and eventually end and even reverse MS progression