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This is extremely rare with peptides but requires immediate response - Chest pain or significant heart rate changes after starting a new peptide, especially if you take cardiovascular medications Contact your provider within 24 hours for: - Persistent nausea or vomiting that doesn't resolve within 24 hours of starting a new compound - Injection site reactions that spread, worsen, or show signs of infection (increasing redness, warmth, streaking) - Significant mood changes (anxiety, agitation, depression) after adding a new peptide to your protocol - Unusual swelling, particularly in hands, feet, or face (can indicate fluid retention from GH peptides) Keep your provider's contact information easily accessible