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Srebp-controlled glucose metabolism is essential for NK cell functional responses

De Bleser PJ, Xu G, Rombouts K, Rogiers V, Geerts A (1999) Glutathione levels discriminate between oxidative stress and transforming growth factor- signaling in activated rat hepatic stellate cells

for a schematic overview of the pathways see Figure 6

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They combined bilirubin and polyethylene glycol into a coupling via a steady amide bond and loaded the anticancer drug doxorubicin (DOX) into BRNPs via film-forming and rehydration to form DOX-loaded BRNPs (DOX@BRNPs)