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The neuroprotective effects of GPE and cGP after intracerebroventricular (icv) administration are dose-dependent, suggesting receptor-mediated pharmacodynamics 12

In human fibroblast cultures, this has been shown to extend the "Hayflick limit" (the number of times a cell can divide) by over 10 passages

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Glycine can also be cleaved by the mitochondrial glycine cleavage system to yield 5,10-methylene-THF, which enters the folate cycle (Tibbetts and Appling, 2010)